CNAG – The Institute

The Centro Nacional de Análisis Genómico (CNAG) is one of the largest Genome Sequencing Centers in Europe.

The CNAG Consortium aims to carry out large-scale projects in DNA/RNA analysis for the improvement of quality of life in collaboration with the Spanish, European and International Research Community. CNAG researchers participate in major International Genome Initiatives such as the Human Cell Atlas (HCA), the International Cancer Genome Consortium (ICGC), the International Human Epigenome Consortium (IHEC), the International Rare Diseases Research Consortium (IRDiRC), the European Reference Genome Atlas (ERGA) and the European Infrastructure for life-science information (ELIXIR), as well as in several EU-funded projects.

CNAG occupies approximately 1,400 square meters of laboratory and office space and operates 4 Illumina instruments (3 NovaSeq6000 and 1 MiSeq) and 2 large Oxford Nanopore Technologies sequencers (1 PromethION 24 and 1 GridION Mk1) that produce more than 7 Tbases of sequencing data per day. The sequencing operation is supported by an extensive informatics infrastructure: 15 petabyte of data storage, 10.000 computing cores and an internal 56 Gb/s network. The operation is certified ISO 9001 and accredited ISO 17025 and serves to deliver standardized, high-quality data for research and clinics. CNAG has highly developed single-cell operation equipped with a 10x Chromium X, 10x Chromium Connect, MissionBio Tapetri for individual cell analyses and for tissue analysis a Nanostring CosMx, 10x Visium, Stereo-seq, and VUTARA VXL.

The CNAG has more than 100 professionals, structured in different units such Bioinformatics, Sequencing, Single-cell, Research, and Corporate Management. 

The Role

The Structural Genomics Group headed by Marc A. Marti-Renom and hosted at the CNAG and the Genome Biology Program of the CRG is seeking a PhD student for his project REVTRANSLOC funded by the Ministerio de Ciencia, Innovación y Universidades of Spain (project number PID2023-151484NB-I00). The Project has an associated FPI to carry a PhD in our lab during a period of 4 years.

The project evolves will aim at reverting the effects of a translocation in the expression of a resulting protein fusion using the genome 3D organization as a template, as it plays a role on how chromosomal translocations contribute to gene activation by means of the so-called “enhancer hijacking. We are looking for candidates with a degree in biology or related fields and a Master in genomics/genetics. Experience in wet lab and computational analysis will be a plus, especially in methods related to ChIP-seq, CUR&RUN or similar. The candidate will actively participate in our project entitled “Reversing the effect of t(9;11) translocation in Acute Myeloid Leukemia (AML)”.

We are looking for a highly motivated and creative thinking individual who is interested in working in an environment where the technical sophistication of structural genomics technologies meets innovative approaches for interpreting data and generating new knowledge. We require the ability for working in a multi-disciplinary context on collaborative projects.

Please, visit our web site at http://marciuslab.org to see our work and all publications from the group.

Whom would we like to hire?

• Bachelor’s degree AND master’s degree in genomics/genetics or related fields

• Experience with NGS technologies.

• Good organizational, prioritizing, communication and interpersonal skills.

• Good spoken and written English.

It would be nice to have:

• Experience with genomics data analysis.

Specific tasks:

- Experimentally assay with NGS technologies.

- Cell culture and basic Molecular Biology techniques.

- Analysis of NGS datasets.

The Offer

• Contract duration: 4 years

• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.

• Target start date: as soon as possible

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

We are committed to reconcile a work and family life for our employees and are offering the opportunity to benefit from annual leave and flexible working hours.

Application Procedure

All applications must include:

• A complete CV including contact details.

• Contact details of two referees.

All applications must be addressed to Dr. Marc A. Marti-Renom – martirenom@cnag.eu / mireya.fernandez@cnag.eu

Deadline: Please submit your application by 30/11/2024

Interview: Shortlisted candidates may be invited for interview at CNAG during October – November  2024

Please, see all our job opportunities in the Career site of CNAG website: https://www.cnag.cat/jobs