Genome of Europe (GoE) is the most extensive EU-funded program on population genomics to date, “Genome of Europe” (GoE). This groundbreaking initiative will establish a unique pan-European reference database of at least 100,000 genomes to generate the reference genome through integration of genome datasets from diverse national populations – all for the benefit of personalised health care. The reference database will represent Europe’s diverse populations, integrating existing genomic datasets and new genomic data through de novo sequencing of distinct national populations. The project encompasses 49 partners across 27 European countries (26 EU + 1 non-EU) and is backed by €45 million in funding with 20 million coming from the EU under the Digital Europe Programme by the European Commission.

Genome of Europe is part of the 1+Million Genomes (1+MG) initiative. Genome of Europe advances this mission by evaluating the long-term potential of genomic sequencing in biomedical research and its integration into European healthcare systems, providing a robust ethical and legal framework, and ensuring secure data management. To achieve this, the project will leverage infrastructure developed by another European program, the European Genomic Data Infrastructure (European GDI).