Oocyte development in Drosophila melanogaster is an interesting model of developmental processes and their timing, especially when localization of crucial components, formation of dorsal-ventral axis and segmentation is considered. Early development in fruit fly is has been previously studied by...

Biomarkers have become increasingly important clinical and research tools in life sciences. They have the potential to validatenovel drug targets and pathways, confirm mechanism of action, support clinical proof of concept, monitor and predict response to therapy. Developed and validated properly,...

The European Bioinformatics Institute (EMBL-EBI) hosts several genomic databases and repositories widely accessed (over a million unique users in 2009), our interaction with our large user community, alongside our involvement in numerous European and International consortia allows us to review the...

During the last few years, the resolution available to interrogate the genomes by means of techniques like next-generation sequencing, genotyping, transcriptomics, proteomics, etc., has undergone an amazing increase.   However, the subsequent conventional single-marker approaches used to...

Sun-exposed human skin contains an extensive number of phenotypicallyintact cell compartments bearing missenseand nonsense mutations in the p53 tumor suppressor gene.   Deep sequencing of sun-exposed and shielded microdissectedskin from mid-life individuals revealed that persistent p53...