We used a hybridization approach to enrich the DNA from 17,367 protein-coding genes in two Neandertal individuals from Spain and Croatia. By analyzing these two exomes together with the genome sequence of a Neandertal from Siberia we show that the genetic diversity of Neandertals was lower than...

Hematopoiesis, where a single hematopoietic stem cell gives rise to the entire blood system, is an important model for differentiation with great medical importance. While the hematopoietic system is perhaps the most characterized model system of cellular commitment and differentiation, we...

Over 30 million Europeans are affected by one of the known 7,000 rare diseases. Symptoms are usually chronic, degenerative and life-threatening; in fact, 30% of patients die before their 5th birthday and there is no effective treatment for the large majority of rare diseases.   Most rare diseases...

Chromatin plays a major regulatory role in development. The current dogma of cellular differentiation presents a model of progressive closing of the regulatory potential of the genome during cellular differentiation.   According to this model, differentiation is a gradual transition from an open...

Next generation sequencing has brought epigenomics to the frontline of current research. In this symposium we want to bring together scientists of different fields who have carried out epigenome analysis projects in collaboration with the CNAG and who will present their latest research discoveries...

The main focus of our laboratory is the investigation of molecular mechanisms that lead to the erasure of epigenetic memory at both histone and DNA modification level.   Major epigenetic changes are connected with the process of epigenetic reprogramming in vivo and in vitro. The current in vitro...