Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes
Microbial eukariotes cover the widest phylogenetic diversity in the eukaryotic tree of life and are essential components of all Earth’s ecosystems. Paradoxically, they remain large unknown, hiding a wealth of genes and genomes that are key to understand the ecology and evolution of microbial...
Coordinator: Ramon Massana (ICM-CSIC, Spain)
Breast CAncer STratification - Understanding the determinants of risk and prognosis of molecular breast cancer subtypes. The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develo
The B-CAST project (Breast CAncer STratification) is coordinated by the Netherlands Cancer Institute Antoni Van Leeuwenhoek and it will be conducted over five years (until September 2020). Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental...
Coordinator: Marjanka Schmidt
A distributed infrastructure for life-science information - Building a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine, agriculture, bioindustries and society
From September 2015, ‘ELIXIR-EXCELERATE’ is facilitating the integration of Europe’s bioinformatics resources, supporting all sectors of life-science R&D. It will deliver excellence to ELIXIR’s users by fast-tracking the development and deployment of essential data services. EXCELERATE funding...
Coordinator: Niklas Bloomberg
Dynamics of human genome architecture in stable and transient gene expression changes
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output...
Coordinator: Miguel Beato
Exploration of non-random Somatic Mutations in Cancer Genomes
Cancer is a disease of the genome. Somatic mutations accumulate on top of the germline genome from many exogenous insults that we are constantly exposed to. If mutations are not removed or repaired they can result in progression to cancer disease. It is know that many of the insults we are exposed...
Coordinator: Ivo Gut
Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer
Buruli ulcer (BU) is a neglected emerging infectious disease caused by Mycobacterium ulcerans. BU has become the third most prevalent mycobacteriosis worldwide, after tuberculosis and leprosy. Limited knowledge of the disease and the fact that it affects mainly poor rural communities contribute to...
Coordinator: Jorge Pedrosa

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